Dr. Pandolfi

Pier Paolo Pandolfi, M.D., Ph.D.

Education and Background

Pier Paolo Pandolfi received his M.D. in 1989 and his Ph.D. in 1995 from the University of Perugia, Italy, after having studied Philosophy at the University of Rome, Italy. He received post-graduate training at the National Institute for Medical Research and the University of London in the UK. He became an Assistant Member of the Molecular Biology Program and the Department of Human Genetics at Memorial-Sloan-Kettering Cancer Center in 1994. Dr. Pandolfi grew through the ranks to become a Member in the Cancer Biology and Genetics Program at the Sloan Kettering Institute; Professor of Molecular Biology and Human Genetics at the Weill Graduate School of Medical Sciences at Cornell University; Professor, Molecular Biology in Pathology and Laboratory Medicine, Weill Medical College at Cornell University; and Head of the Molecular and Developmental Biology Laboratories at MSKCC. Dr. Pandolfi was also the incumbent of the Albert C. Foster Endowed Chair for Cancer Research at Memorial Sloan-Kettering Cancer Center.
Dr. Pandolfi currently holds the Reisman Endowed Chair of Medicine, and is Professor of Medicine and Pathology at Harvard Medical School (HMS). He joined the HMS faculty at Beth Israel Deaconess Medical Center (BIDMC) in 2007 to serve as Scientific Director of the Cancer Center, the Director of the Cancer Genetics Program, and the Chief of the Division of Genetics in the Department of Medicine; he is also a Member of the Department of Pathology at BIDMC. He was recently appointed to serve as the Cancer Center Director and the Director of the Cancer Research Institute at BIDMC and HMS.

Research Overview

The research carried out in Dr. Pandolfi’s laboratory has been seminal to elucidating the molecular mechanisms and the genetics underlying the pathogenesis of leukemias and solid tumors, as well as in modeling these cancers in the mouse. Dr. Pandolfi and his team have characterized the function of the fusion oncoproteins and the genes involved in the chromosomal translocations of acute promyelocytic leukemia (APL), as well as of major tumor suppressors such as PTEN, PML and p53, and novel cancer genes such as POKEMON and INPP4B. The elucidation of the molecular basis underlying the pathogenesis of APL has led to the development of novel and effective therapeutic strategies. As a result of these efforts, APL is now considered a curable disease. Additional novel therapeutic concepts have emerged from this work and are currently being tested in clinical trials. More recently, Dr. Pandolfi and colleagues have presented a new theory describing how RNAs, both protein coding and non-coding, exert their biological functions with profound implications for human genetics, cell biology and cancer biology.

Professional Memberships

Dr. Pandolfi is also a member of the following organizations:
1997-Present; Member, American Society of Hematology
1999-Present; Member, American Association for Cancer Research
2006-Present; Member, American Society for Clinical Investigation (ASCI)
2006-Present; Member, American Association of Physicians (AAP)
2007-Present; Member, European Molecular Biology Organization (EMBO)
2013-Present; Member, American Association for the Advancement of Science

Awards and Other Honors

Dr. Pandolfi has received numerous awards including:
1997 Leukemia Society of America Scholar Award
1999 Louise and Allston Boyer Young Investigator Award in Biomedical Research
1999 Alexandra J. Kefalides Memorial Prize for Leukemia Research
2000 Hamdan Award for Medical Research Excellence
2001 Weizmann Institute of Science: Sergio Lombroso Prize for Cancer Research
2002 Leukemia and Lymphoma Society Stohlman Scholar Award
2004 William and Linda Steere Foundation Award
2005 Albert C. Foster Endowed Chair for Cancer Research / MSKCC
2005 American-Italian Cancer Foundation Prize for Scientific Excellence in Medicine
2005 National Institutes of Health / National Cancer Institute MERIT Award
2006 Science Award, “La Scuola d’Italia Guglielmo Marconi”, New York City
2007 Honorary Master’s Degree – Harvard Medical School
2008 George C. Reisman Endowed Chair / Harvard Medical School
2009 Prostate Cancer Foundation Creativity Award
2011 Pezcoller Foundation-AACR International Award for Cancer Research
2012 International Award for Medicine – Premio “Scanno”-Tanturri Foundation
2013 Ethic International Award in Biomedicine – Oscar Pomilio Foundation
2013 European Foundation Guido Venosta Award for Cancer Research
2014 America International Award 2015 NIH/NCI Outstanding Investigator Award
2015 “Knighthood” from the Italian President: Medal of Honor of the Star of Italy
2017 American Association for the Advancement of Science Fellowship