Team Members

Our Team

The Pandolfi laboratory has been seminal at elucidating the fundamental molecular mechanisms and the diverse genetics underlying the pathogenesis of leukemias and solid tumors, as well as in deconstructing these processes and modeling these cancers, in vivo, in the mouse.

Dr. Pandolfi and colleagues have characterized the function of the fusion oncoproteins and the genes involved in the chromosomal translocations of acute promyelocytic leukemia (APL). The lab has also characterized the function of major tumor suppressors such PTEN and p53 and novel cancer genes such as POKEMON and INPP4B.

The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel and effective therapeutic strategies. As a result of these efforts, APL is now considered a curable disease. Novel therapeutic concepts have emerged from this work that are currently been tested in clinical trials.

More recently, the lab has embraced and pioneered the non-coding RNA revolution identifying and characterizing micro RNAs, circular RNAs, long non-coding RNAs, and pseudogenes implicated in tumorigenesis.

Team Members:

Assaf C. Bester, PhD

PostDoctoral Fellow

Research Focus: role of long-non coding RNA in cancer

PhD Hebrew University in Jerusalem (Israel)

M.S. Hebrew University in Jerusalem (Israel)

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Marco Bezzi, PhD

PostDoctoral Fellow

Research Focus: role of RNA processing in cancer biology.

PhD National University of Singapore

M.S. St.Orsola-Malpighi Polyclinic, Bologna (Italy)

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Giulia Cheloni

Giulia Cheloni, PhD

PostDoctoral Fellow

Research Focus: role of circRNAs in Leukemia.

PhD Università degli Studi di Firenze, Italy

M.S. Università degli Studi di Firenze, Italy

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Ming Chen, PhD

PostDoctoral Fellow

Research Focus: molecular events underlying progression to metastasis

PhD University of Rochester (NY)

M.S. East China Normal University, Shanghai (China)

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Jlenia Guarnerio, PhD

PostDoctoral Fellow

Research Focus:.role of circRNAs in sarcoma and mesenchymal stem cells transformation

PhD University Vita-Salute San Raffaele, Milan (Italy)

M.S. University Vita-Salute San Raffaele, Milan (Italy)

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Yu-Ru Lee, PhD

PostDoctoral Fellow

Research Focus: roles of PTEN post-translational and post-transcriptional regulation in tumor progression

PhD School of Molecular Medicine, National Taiwan University (Taiwan)

M.S. School of Biochemistry and Molecular Biology, National Yang-Ming University (Taiwan)

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Akinobu Matsumoto, PhD

PostDoctoral Fellow

Research Focus: role of polypeptides encoded by long non-coding RNAs.

PhD Kyushu University (Japan)

M.S. Kyushu University (Japan)

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Lourdes M. Mendez, MD, PhD

PostDoctoral Fellow

Research Focus: role of PPARs and fatty acid metabolism in AML

MD/PhD Albert Einstein College of Medicine

M.S. Harvard University

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Vera Mugoni, PhD

PostDoctoral Fellow

Research Focus: targeting resistances in AML.

PhD Molecular Biotechnology Center of Torino (Italy)

M.S. University of Torino (Italy)

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Daphna Nachmani, PhD

PostDoctoral Fellow

Research Focus: post-transcriptional and translational regulation in the hematopoietic system.

PhD Hebrew University of Jerusalem (Israel)

M.S. Hebrew University of Jerusalem (Israel)

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Riccardo Panella, PhD

PostDoctoral Fellow

Research Focus: role of miRNAs in cancer, developing of RNA based therapies

PhD Universitá degli Studi Di Perugia (Italy)

M.S. Universitá degli Studi Di Perugia (Italy)

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Yulia Shulga, PhD

PostDoctoral Fellow

Research Focus: cancer stem cells, identification of novel biomarkers and drug targets in prostate cancer

PhD McMaster University (Canada)

M.S. Novosibirsk State University (Russia)

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yang zhang

Yang Zhang, PhD

PostDoctoral Fellow

Research Focus: role of circRNAs in liver cancer

PhD Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

M.S. Jilin University, Changchun, China

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Joshua Victor, M.S

Senior Research Assistant

Archita Menon, M.S

Research Assistant

Jesse Katon, B.S

Research Assistant

Caitlin Mitchel, B.S

Research Assistant

Letizia Longo, PhD

Lab Supervisor

John Clohessy, PhD

Director of Preclinical Murine Pharmacogenetics Core

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Lauren Southwood

Executive Assistant to Dr. Pier Paolo Pandolfi
Office of the Director

Elizabeth Stack

Administrative Coordinator

Out of the Lab