The Pandolfi laboratory has been seminal at elucidating the fundamental molecular mechanisms and the diverse genetics underlying the pathogenesis of leukemias and solid tumors, as well as in deconstructing these processes and modeling these cancers, in vivo, in the mouse.
Dr. Pandolfi and colleagues have characterized the function of the fusion oncoproteins and the genes involved in the chromosomal translocations of acute promyelocytic leukemia (APL). The lab has also characterized the function of major tumor suppressors such PTEN and p53 and novel cancer genes such as POKEMON and INPP4B.
The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel and effective therapeutic strategies. As a result of these efforts, APL is now considered a curable disease. Novel therapeutic concepts have emerged from this work that are currently been tested in clinical trials.
More recently, the lab has embraced and pioneered the non-coding RNA revolution identifying and characterizing micro RNAs, circular RNAs, long non-coding RNAs, and pseudogenes implicated in tumorigenesis.
Takahiro Kiskikawa, MD, PhD
Research Focus: role of non-coding RNA in pancreatic cancer
PhD Graduate School of Medicine, The University of Tokyo, Japan
MD The University of Tokyo, Japan
Yu-Ru Lee, PhD
Research Focus: roles of PTEN post-translational and post-transcriptional regulation in tumor progression
PhD School of Molecular Medicine, National Taiwan University (Taiwan)
M.S. School of Biochemistry and Molecular Biology, National Yang-Ming University (Taiwan)
Daphna Nachmani, PhD
Research Focus: post-transcriptional and translational regulation in the hematopoietic system.
PhD Hebrew University of Jerusalem (Israel)
M.S. Hebrew University of Jerusalem (Israel)
Riccardo Panella, PhD
Research Focus: role of miRNAs in cancer, developing of RNA based therapies
PhD Universitá degli Studi Di Perugia (Italy)
M.S. Universitá degli Studi Di Perugia (Italy)
Yulia Shulga, PhD
Research Focus: cancer stem cells, identification of novel biomarkers and drug targets in prostate cancer
PhD McMaster University (Canada)
M.S. Novosibirsk State University (Russia)
Yang Zhang, PhD
Research Focus: role of circRNAs in liver cancer
PhD Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
M.S. Jilin University, Changchun, China
Jonathan D. Lee, M.A.
Research Focus: role of long noncoding RNAs in cancer
M.A. Harvard University
Joshua Victor, M.S
Senior Research Assistant
Alison Guzzetti, B.S.
Caitlin Mitchel, B.S
Letizia Longo, PhD
Executive Assistant to Dr. Pier Paolo Pandolfi
Office of the Director