Jlenia Guarnerio

Jlenia Guarnerio, PhD

Education/Training:

Jlenia received her PhD degree in Molecular Medicine in 2012 at University Vita-Salute San Raffaele, Milan. She joined Pier Paolo Pandolfi’s lab as part of her PhD training in September 2010, and then she stayed in Pandolfi’s lab for her post-doctoral training. During her PhD training, she worked mainly on the role of hypoxia inducible factors (HIF1α and HIF2α) in the non cell-autonomous regulation of Hematopoietic stem cell niche, and she developed a new platform to study molecular drivers responsible for the generation of mesenchymal tumors. During the post-doctoral period she started to work on circular RNAs, and she is currently developing these studies in the setting of sarcoma. She was a recipient of a post-doctoral fellowship from the American Italian Cancer Foundation in August 2013, and she got the K99 pathway of independence award in September 2016.

Current Projects:

Jlenia is currently developing three independent projects:

Dissecting the non-cell-autonomous role of PML, expressed in bone-marrow stromal cells, in sustaining leukemic stem cells.

Investigating the Role of the circular RNA derived from the Zbtb7a gene in the development of sarcoma.

Screening of protein-coding genes and circular RNAs responsible for the transformation of mesenchymal stem cells.