Publications

M. Bezzi, N. Seitzer, T. Ishikawa, M. Reschke, M. Chen, G. Wang, C. Mitchell, C. Ng, J.M. Katon, A. Lunardi, S. Signoretti, J.G. Clohessy, J. Zhang, P.P. Pandolfi. “Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.” Nature Medicine. 2018 Feb;24(2):165-175.

M. Chen, J. Zhang, K. Sampieri, J.G. Clohessy, L. Mendez, E. Gonzalez-Billalabeitia, X.S. Liu, Y. Lee, J. Fung, J.M. Katon, A. Venugopal Menon, K.A. Webster, C. Ng, M. Dilia Palumbieri, M.S. Diolombi, S.B. Breitkopf, J. Teruya-Feldstein, S. Signoretti, R.T. Bronson, J.M. Asara, M. Castillo-Martin, C. Cordon-Cardo, P.P. Pandolfi. “An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.” Nat Genetics 2018 Feb;50(2):206-218.

M. Chen, L. Wan, J. Zhang, J. Zhang, L. Mendez, JG. Clohessy, K. Berry, J. Victor, Q. Yuan, W. Wei and P.P. Pandolfi. “Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.” Nat Commun. 2018 Jan 15;9(1):159

J. Guarnerio, L.M. Mendez, N. Asada, A. Venugopal Menon, J. Fung, K. Berry, P.S. Frenette, K. Ito, P.P. Pandolfi. “A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.” Nat.Comm. 2018 Jan 4;9(1):66

A. Matsumoto, A. Pasut, M. Matsumoto, R. Yamashita, J. Fung, E. Monteleone, A. Saghatelian, K.I. Nakayama, J.G. Clohessy, P.P. Pandolfi. “mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.” Nature. 2017 Jan 12;541(7636):228-23.

J. Guarnerio, M. Bezzi, J.C. Jeong, S.V. Paffenholz, K. Berry, M.M. Naldini, F. Lo-Coco, Y. Tay, A.H. Beck, P.P. Pandolfi. “Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations”. Cell. 2016 Apr 7;165(2):289-302.

F.A. Karreth, M. Reschke, A. Ruocco, C. Ng, B. Chapuy, V. Léopold, M. Sjoberg, T.M. Keane, A. Verma, U. Ala, Y. Tay, N. Seitzer, A. Bothmer, J. Fung, F. Langellotto, S.J. Rodig, O. Elemento, M.A. Shipp, D.J. Adams, R. Chiarle, P.P. Pandolfi. 2015. “The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.” Cell, 2015 Apr 9; 161(2):319-32.

A. Papa, L. Wan, M. Bonora, L. Salmena, M.S. Song, R.M. Hobbs, A. Lunardi, K. Webster, C. Ng, R.H. Newton, N. Knoblauch, J. Guarnerio, K. Ito, L.A. Turka, A.H. Beck, P. Pinton, R.T. Bronson, W. Wei, P.P. Pandolfi. Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell, 2014 Apr 24; 157(3): 595-610.

Y. Tay, J. Rinn, P.P. Pandolfi. The multilayered complexity of ceRNA crosstalk and competition. Nature, 2014 Jan 16; 505(7483): 344-52.

J. Lieberman, F. Slack, P.P. Pandolfi. Non-coding RNAs and cancer. Cell, 2013 March 28; 153(1):9-10.

S. J. Song, L. Poliseno, M.S. Song, U. Ala, L. Kats, G. Beringer, K. Webster, X. Yuan, J.E. Brock, A. L. Richardson, L. C. Cantley, P.P. Pandolfi. MicroRNA-antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling. Cell, 2013 Jul 18; 154(2):311-24.

I. Garcia-Cao, M.S. Song, R.M. Hobbs, G. Laurent, C. Giorgi, V.C.J. de Boer, D. Anastasiou, K. Ito, A. Sasaki, L. Rameh, A. Carracedo, M.G.Vander Heiden, L.C. Cantley, P. Pinton, M.C Haigis, P.P. Pandolfi. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell, 2012 Mar 30; 149(1):49-62.

F.A. Karreth, Y. Tay, D. Perna, U. Ala, A.G. Rust, K.A. Webster, D. Weiss, P.A. Perez-Mancera, M. Krauthammer, R. Halaban, P. Provero, D.J. Adams, D.A. Tuveson and P.P. Pandolfi. In vivo identification of tumor suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell, 2011 Oct 14; 147(2): 382-395. Erratum: Nov 11; 147 (4): 948.

Y. Tay, L. Kats, L. Salmena, D. Weiss, S.M. Tan, U. Ala, F. Karreth, L. Poliseno, P. Provero, F. Di Cunto, J. Lieberman, I. Rigoutsos and P.P. Pandolfi. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011 Oct 14; 147 (2): 344-357. Highlighted on cover.

H. K. Lin, Z. Chen, G. Wang, C. Nardella, K.I. Nakayama, C. Cordon-Cardo, J. Teruya-Feldstein, S.W. Lee, C. H. Chan, W.L. Yang, J. Wang, A. Egia and P.P. Pandolfi. Skp2 targeting suppresses tumorigenesis in vivo through induction of cellular senescence independently of p19Arf/p53. Nature, 464:374-9, 2010. Erratum in: Nature. 2010 Jul 15; 466:398. Chan, Chan-Hsin [corrected to Chan, Chia-Hsin].

B.S. Carver, J. Tran, Z. Chen, A. Carracedo-Perez, A. Alimonti, C. Nardella, A. Gopalan, P.T. Scardino, C. Cordon-Cardo, W. Gerald, and P.P. Pandolfi. ETS genetic rearrangements are progression events in prostate tumorigenesis. Nature, 457:E1; discussion E2-3, 2009

M.S. Song, L. Salmena, A. Carracedo-Perez, A. Egia, F. Lo Coco, J. Teruya-Feldstein and P.P. Pandolfi. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature, 455:813-7, 2008, Epublished 2008 20 August.

K. Ito, R. Bernardi, A. Morotti, S. Matsuoka, G. Saglio, Y. Ikeda, J. Rosenblatt. D.E. Avigan, J. Teruya-Feldstein and P.P. Pandolfi. PML targeting eradicates quiescent leukemia initiating cells. Nature, 453:1072-8, 2008, Epublished 2008 May 11.

A. Carracedo-Perez, L. Salmena and P.P. Pandolfi. Snapshot: PTEN Signaling Pathways. Cell, 133: 550-550.e1, 2008.

L. Salmena, A. Carracedo-Perez, and P.P. Pandolfi. Tenets of PTEN tumor suppression. Cell, 133: 403-414, 2008.

T. Maeda, T. Merghoub, R.M. Hobbs, L. Dong, M. Maeda, J. Zakrzewski, M.R.M. van den Brink, A. Zelent, H. Shigematsu, K. Akashi, J. Teruya-Feldstein, G. Cattoretti and P.P. Pandolfi. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science, 316: 860-866, 2007.

L.C. Trotman, X. Wang, A. Alimonti, Z. Chen, J. Teruya-Feldstein, S-G. Chi, H-J. Kim, H. Yang, N.P. Pavletich, B.S. Carver, H. Erdjument-Bromage, P. Tempst, C. Cordon-Cardo, T. Misteli. X. Jiang and P.P. Pandolfi. Ubiquitination regulates nuclear PTEN import and tumor suppression. Cell, 128:141-56, 2007.

R. Bernardi, I. Guernah, D. Jin, C. Cordon-Cardo, M. Celeste Simon, S. Rafii and P.P. Pandolfi. PML inhibits Hif-1 translation and neoangiogenesis through repression of mTOR. Nature, 442:779-785, 2006.

P.P. Scaglioni, T. Yung, L-F Cai, H. Erdjument-Bromage, B. Singh, J. Teruya-Feldstein, P. Tempst and P.P. Pandolfi. A novel CK2-dependent pathway for PML degradation upon cellular and oncogenic stress. Cell, 126:269-283, 2006.

L.C. Trotman, A. Alimonti, P.P. Scaglioni, J.A. Koutcher, C. Cordon-Cardo and P.P. Pandolfi. Identification of a tumour suppressor network opposing nuclear Akt function. Nature, 441:523-7 2006.

S. Grisendi, R. Bernardi, M. Rossi, K. Cheng, L. Khandker, K. Manova and P.P. Pandolfi. Role of Npm in embryonic development and tumourigenesis. Nature, 437:147-53, 2005.

Z. Chen, L.C. Trotman, D. Shaffer, H.-K. Lin, Z.A. Dotan, M. Niki, J.A. Koutcher, H.I. Scher, T. Ludwig, W. Gerald, C. Cordon-Cardo and P.P. Pandolfi. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis, Nature, 436:725-730, 2005.

L. Ma, Z. Chen, H. Erdjument-Bromage, P. Tempst and P.P. Pandolfi. Phosphorylation and functional inactivation of TSC2 by Erk: implications for tuberous sclerosis and cancer pathogenesis. Cell, 121:155-317, 2005.

T. Maeda, R. Hobbs, T. Merghoub, I. Guernah, A. Zelent, C. Cordon-Cardo, J. Teruya-Feldstein and P.P. Pandolfi. Role of the proto-oncogene POKEMON in cellular transformation and ARF repression. Nature, 433:278-285, 2005.

D. Ruggero, S. Grisendi, F. Piazza, E. Rego, F. Mari, C. Cordon-Cardo and P.P. Pandolfi. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science, 299:259-262, 2003.

H.-K. Lin, S. Bergmann and P.P. Pandolfi. Cytoplasmic PML function in TGF-beta signaling. Nature, 431:205-11, 2004.

A. Di Cristofano and P.P. Pandolfi. The multiple roles of PTEN in tumor suppression. Cell, 100:387-390, 2000.

A. Di Cristofano, P. Kotsi, Y.F. Peng, C. Cordon-Cardo, K. Elkon and P.P. Pandolfi. Impaired Fas response and autoimmunity in PTEN +/- mice. Science, 285:2122-2125, 1999.