Publications

M. Chen, J. Zhang, A.H. Berger, M.S. Diolombi, C. Ng, J. Fung, R.T. Bronson, M. Castillo-Martin, T.H. Thin, C. Cordon-Cardo, R. Plevin, P.P. Pandolfi. “Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis”. J. Clin. Invest. 2018 Nov. 26, pii: 99699. doi: 10.1172/JCI99699. [Epub ahead of print].

Y.R. Lee, M. Chen, P.P. Pandolfi. “The functions and regulation of the PTEN tumor suppressor:new model and prospects”. Nat. Rev. Mol. Cell. Biol. 2018 Sep;19(9):547-562

A.C. Bester, J.D. Lee, A. Chavez, Y.R. Lee, D. Nachmani, S. Vora, J. Victor, M. Sauvageau, J.L. Rinn, P. Provero, G.M. Church, , J.G. Clohessy, P.P. Pandolfi. An Integrated Genome Wide CRISPRa Approach to Study Drug Resistance Uncovers Coding and Noncoding Networks. Cell, 2018 Apr Cell. 2018 Apr 19;173(3):649-664.

M. Bezzi, N. Seitzer, T. Ishikawa, M. Reschke, M. Chen, G. Wang, C. Mitchell, C. Ng, J.M. Katon, A. Lunardi, S. Signoretti, J.G. Clohessy, J. Zhang, P.P. Pandolfi. “Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.” Nature Medicine. 2018 Feb;24(2):165-175.

M. Chen, J. Zhang, K. Sampieri, J.G. Clohessy, L. Mendez, E. Gonzalez-Billalabeitia, X.S. Liu, Y. Lee, J. Fung, J.M. Katon, A. Venugopal Menon, K.A. Webster, C. Ng, M. Dilia Palumbieri, M.S. Diolombi, S.B. Breitkopf, J. Teruya-Feldstein, S. Signoretti, R.T. Bronson, J.M. Asara, M. Castillo-Martin, C. Cordon-Cardo, P.P. Pandolfi. “An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.” Nat Genetics 2018 Feb;50(2):206-218.

M. Chen, L. Wan, J. Zhang, J. Zhang, L. Mendez, JG. Clohessy, K. Berry, J. Victor, Q. Yuan, W. Wei and P.P. Pandolfi. “Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.” Nat Commun. 2018 Jan 15;9(1):159

J. Guarnerio, L.M. Mendez, N. Asada, A. Venugopal Menon, J. Fung, K. Berry, P.S. Frenette, K. Ito, P.P. Pandolfi. “A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.” Nat.Comm. 2018 Jan 4;9(1):66

A. Matsumoto, A. Pasut, M. Matsumoto, R. Yamashita, J. Fung, E. Monteleone, A. Saghatelian, K.I. Nakayama, J.G. Clohessy, P.P. Pandolfi. “mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.” Nature. 2017 Jan 12;541(7636):228-23.

J. Guarnerio, M. Bezzi, J.C. Jeong, S.V. Paffenholz, K. Berry, M.M. Naldini, F. Lo-Coco, Y. Tay, A.H. Beck, P.P. Pandolfi. “Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations”. Cell. 2016 Apr 7;165(2):289-302.

F.A. Karreth, M. Reschke, A. Ruocco, C. Ng, B. Chapuy, V. Léopold, M. Sjoberg, T.M. Keane, A. Verma, U. Ala, Y. Tay, N. Seitzer, A. Bothmer, J. Fung, F. Langellotto, S.J. Rodig, O. Elemento, M.A. Shipp, D.J. Adams, R. Chiarle, P.P. Pandolfi. 2015. “The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.” Cell, 2015 Apr 9; 161(2):319-32.

A. Papa, L. Wan, M. Bonora, L. Salmena, M.S. Song, R.M. Hobbs, A. Lunardi, K. Webster, C. Ng, R.H. Newton, N. Knoblauch, J. Guarnerio, K. Ito, L.A. Turka, A.H. Beck, P. Pinton, R.T. Bronson, W. Wei, P.P. Pandolfi. Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell, 2014 Apr 24; 157(3): 595-610.

Y. Tay, J. Rinn, P.P. Pandolfi. The multilayered complexity of ceRNA crosstalk and competition. Nature, 2014 Jan 16; 505(7483): 344-52.

J. Lieberman, F. Slack, P.P. Pandolfi. Non-coding RNAs and cancer. Cell, 2013 March 28; 153(1):9-10.

S. J. Song, L. Poliseno, M.S. Song, U. Ala, L. Kats, G. Beringer, K. Webster, X. Yuan, J.E. Brock, A. L. Richardson, L. C. Cantley, P.P. Pandolfi. MicroRNA-antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling. Cell, 2013 Jul 18; 154(2):311-24.

I. Garcia-Cao, M.S. Song, R.M. Hobbs, G. Laurent, C. Giorgi, V.C.J. de Boer, D. Anastasiou, K. Ito, A. Sasaki, L. Rameh, A. Carracedo, M.G.Vander Heiden, L.C. Cantley, P. Pinton, M.C Haigis, P.P. Pandolfi. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell, 2012 Mar 30; 149(1):49-62.

F.A. Karreth, Y. Tay, D. Perna, U. Ala, A.G. Rust, K.A. Webster, D. Weiss, P.A. Perez-Mancera, M. Krauthammer, R. Halaban, P. Provero, D.J. Adams, D.A. Tuveson and P.P. Pandolfi. In vivo identification of tumor suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell, 2011 Oct 14; 147(2): 382-395. Erratum: Nov 11; 147 (4): 948.

Y. Tay, L. Kats, L. Salmena, D. Weiss, S.M. Tan, U. Ala, F. Karreth, L. Poliseno, P. Provero, F. Di Cunto, J. Lieberman, I. Rigoutsos and P.P. Pandolfi. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011 Oct 14; 147 (2): 344-357. Highlighted on cover.

H. K. Lin, Z. Chen, G. Wang, C. Nardella, K.I. Nakayama, C. Cordon-Cardo, J. Teruya-Feldstein, S.W. Lee, C. H. Chan, W.L. Yang, J. Wang, A. Egia and P.P. Pandolfi. Skp2 targeting suppresses tumorigenesis in vivo through induction of cellular senescence independently of p19Arf/p53. Nature, 464:374-9, 2010. Erratum in: Nature. 2010 Jul 15; 466:398. Chan, Chan-Hsin [corrected to Chan, Chia-Hsin].

B.S. Carver, J. Tran, Z. Chen, A. Carracedo-Perez, A. Alimonti, C. Nardella, A. Gopalan, P.T. Scardino, C. Cordon-Cardo, W. Gerald, and P.P. Pandolfi. ETS genetic rearrangements are progression events in prostate tumorigenesis. Nature, 457:E1; discussion E2-3, 2009

M.S. Song, L. Salmena, A. Carracedo-Perez, A. Egia, F. Lo Coco, J. Teruya-Feldstein and P.P. Pandolfi. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature, 455:813-7, 2008, Epublished 2008 20 August.

K. Ito, R. Bernardi, A. Morotti, S. Matsuoka, G. Saglio, Y. Ikeda, J. Rosenblatt. D.E. Avigan, J. Teruya-Feldstein and P.P. Pandolfi. PML targeting eradicates quiescent leukemia initiating cells. Nature, 453:1072-8, 2008, Epublished 2008 May 11.

A. Carracedo-Perez, L. Salmena and P.P. Pandolfi. Snapshot: PTEN Signaling Pathways. Cell, 133: 550-550.e1, 2008.

L. Salmena, A. Carracedo-Perez, and P.P. Pandolfi. Tenets of PTEN tumor suppression. Cell, 133: 403-414, 2008.

T. Maeda, T. Merghoub, R.M. Hobbs, L. Dong, M. Maeda, J. Zakrzewski, M.R.M. van den Brink, A. Zelent, H. Shigematsu, K. Akashi, J. Teruya-Feldstein, G. Cattoretti and P.P. Pandolfi. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science, 316: 860-866, 2007.

L.C. Trotman, X. Wang, A. Alimonti, Z. Chen, J. Teruya-Feldstein, S-G. Chi, H-J. Kim, H. Yang, N.P. Pavletich, B.S. Carver, H. Erdjument-Bromage, P. Tempst, C. Cordon-Cardo, T. Misteli. X. Jiang and P.P. Pandolfi. Ubiquitination regulates nuclear PTEN import and tumor suppression. Cell, 128:141-56, 2007.

R. Bernardi, I. Guernah, D. Jin, C. Cordon-Cardo, M. Celeste Simon, S. Rafii and P.P. Pandolfi. PML inhibits Hif-1 translation and neoangiogenesis through repression of mTOR. Nature, 442:779-785, 2006.

P.P. Scaglioni, T. Yung, L-F Cai, H. Erdjument-Bromage, B. Singh, J. Teruya-Feldstein, P. Tempst and P.P. Pandolfi. A novel CK2-dependent pathway for PML degradation upon cellular and oncogenic stress. Cell, 126:269-283, 2006.

L.C. Trotman, A. Alimonti, P.P. Scaglioni, J.A. Koutcher, C. Cordon-Cardo and P.P. Pandolfi. Identification of a tumour suppressor network opposing nuclear Akt function. Nature, 441:523-7 2006.

S. Grisendi, R. Bernardi, M. Rossi, K. Cheng, L. Khandker, K. Manova and P.P. Pandolfi. Role of Npm in embryonic development and tumourigenesis. Nature, 437:147-53, 2005.

Z. Chen, L.C. Trotman, D. Shaffer, H.-K. Lin, Z.A. Dotan, M. Niki, J.A. Koutcher, H.I. Scher, T. Ludwig, W. Gerald, C. Cordon-Cardo and P.P. Pandolfi. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis, Nature, 436:725-730, 2005.

L. Ma, Z. Chen, H. Erdjument-Bromage, P. Tempst and P.P. Pandolfi. Phosphorylation and functional inactivation of TSC2 by Erk: implications for tuberous sclerosis and cancer pathogenesis. Cell, 121:155-317, 2005.

T. Maeda, R. Hobbs, T. Merghoub, I. Guernah, A. Zelent, C. Cordon-Cardo, J. Teruya-Feldstein and P.P. Pandolfi. Role of the proto-oncogene POKEMON in cellular transformation and ARF repression. Nature, 433:278-285, 2005.

D. Ruggero, S. Grisendi, F. Piazza, E. Rego, F. Mari, C. Cordon-Cardo and P.P. Pandolfi. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science, 299:259-262, 2003.

H.-K. Lin, S. Bergmann and P.P. Pandolfi. Cytoplasmic PML function in TGF-beta signaling. Nature, 431:205-11, 2004.

A. Di Cristofano and P.P. Pandolfi. The multiple roles of PTEN in tumor suppression. Cell, 100:387-390, 2000.

A. Di Cristofano, P. Kotsi, Y.F. Peng, C. Cordon-Cardo, K. Elkon and P.P. Pandolfi. Impaired Fas response and autoimmunity in PTEN +/- mice. Science, 285:2122-2125, 1999.