Researchers Identify Drug Target for ATRA – BIDMC

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Researchers Identify Drug Target for ATRA, the First Precision Cancer Therapy

Discovery offers a new way to fight cancer by targeting the Pin1 enzyme

BOSTON – Targeted cancer therapies work by blocking a single oncogenic pathway to halt tumor growth. But because cancerous tumors have the unique ability to activate alternative pathways, they are often able to evade these therapies — and regrow. Moreover, tumors contain a small portion of cancer stem cells that are believed to be responsible for tumor initiation, metastasis and drug resistance. Thus, eradicating cancer stem cells may be critical for achieving long-lasting remission, but there are no drugs available that specifically attack cancer stem cells.

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